mto1 — Schizosaccharomyces pombe 972h-

Summary

SPCC417.07C (mto1) on chromosome 3 of Schizosaccharomyces pombe encodes a protein with a PEP domain, an Mto2p-binding domain, and a Cnn_1N domain, and is annotated for calmodulin binding. The gene is associated with astral microtubule nucleation, spindle pole body-led chromosome movement during mitotic interphase, microtubule nucleation during interphase by iMTOC, brain development, meiotic telomere clustering, mitotic spindle positioning, kinetochore clustering at the old mitotic spindle pole body, microtubule stabilization, spindle orientation, nuclear migration by microtubule mediated pushing forces, microtubule nucleation, karyogamy, RAM/MOR signaling, cytoplasmic microtubule organization, gene conversion, and mitotic spindle assembly. It localizes to the outer plaque and half bridge of the mitotic spindle pole body, iMTOC, static microtubule bundle, eMTOC, MTOC, actomyosin contractile ring, microtubule cytoskeleton, and microtubule. The gene is also linked to protein content. Studies of related genes in other species connect the family to microtubule organization.