CLB3 — Schizosaccharomyces pombe 972h-

Summary

SPCC4E9.02 (CLB3, also known as cig1) on chromosome 3 of Schizosaccharomyces pombe encodes a cyclin protein containing cyclin-box and cyclin N-terminal domains. It has cyclin-dependent protein serine/threonine kinase activator and regulator activities. The gene is associated with mitotic cell cycle phase transition, regulation of G1/S transition, response to UV-A, negative regulation of ascospore formation, and regulation of reciprocal meiotic recombination. It localizes to the microtubule organizing center, spindle pole bodies, CDK holoenzyme, meiotic and mitotic spindles, and the nuclear periphery. Phenotypic associations include abnormal cell cycle progression through metaphase and anaphase, absent sporulation, and changes in nucleus size and chromosome segregation timing. Studies of related genes in other species link the family to cell cycle control.