MYO1 — Schizosaccharomyces pombe 972h-

Summary

SPCC645.05C, also known as MYO1 or myo2 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a protein containing myosin head and motor domains, a kinesin motor domain superfamily element, and a P-loop NTPase domain. The product exhibits calcium-dependent ATPase activity, microfilament motor activity, calmodulin binding, F-actin binding, small GTPase binding, and ATP hydrolase activity. It is associated with endomembrane organization, actin filament bundle retrograde transport, vesicle transport along actin filaments, spindle pole body separation, Golgi division, centromere separation, abscission, organelle inheritance, nuclear migration during mitotic telophase, cell motility, actomyosin contractile ring assembly, and peroxisome inheritance. The protein localizes to the myosin V complex, microvillus, myosin filament, LINC complex, formin-nucleated actin cables, cortical cytoskeleton, transport vesicles, and gamma-tubulin ring complex. Associations with salt response, cytokinesis, chromosome segregation, cell fusion, mating efficiency, and prion inheritance have been noted.