SNF1 — Schizosaccharomyces pombe 972h-

Summary

SPCC74.03C (SNF1, ssp2) on chromosome 3 of Schizosaccharomyces pombe encodes a serine/threonine protein kinase with protein kinase A activity, ATP binding, and phospholipid binding, belonging to the AMPK family and containing UBA and KA1/Ssp2_C domains. The gene is associated with energy homeostasis, response to glucose, upregulation of gluconeogenesis, and mycose catabolism, as well as positive regulation of cell cycle switching from mitotic to meiotic, negative regulation of cytoplasmic translation and inositol phosphate biosynthesis, and regulation of invasive growth in response to glucose limitation. It is linked to cellular processes including fungal-type cell wall assembly, septin ring assembly, maintenance of cell polarity, and single-species surface biofilm formation. The protein localises to the nucleotide-activated protein kinase complex, perinuclear space, cellular bud neck septin ring, mitotic spindle pole body, and vacuolar membrane. Studies of related genes in other species link the family to turgor pressure and loss of pathogenicity.