SPMIT.01 — Schizosaccharomyces pombe 972h-

Summary

SPMIT.01 (COX1) in Schizosaccharomyces pombe 972h- encodes a protein with cytochrome-c oxidase activity (EC 7.1.1.9), proton-transporting ATP synthase activity, endonuclease activity, and structural molecule activity, and belongs to the LAGLIDADG endonuclease and cytochrome-c oxidase subunit 2 families. The gene is associated with mitochondrial gene expression, intron homing, ATP synthesis coupled electron transport, cellular respiration, and RNA processing. It localises to the respiratory chain complex IV, mitochondrial inner membrane, and mitochondrial chromosome. Phenotypic associations link COX1 to respiratory metabolism, mitochondrial genome maintenance, petite-negative growth, decreased cell size, delayed cell cycle progression, altered biofilm formation, and responses to oxidative stress, alkaline pH, desiccation, and anaerobic conditions. Studies of related genes in other species connect the family to cytochrome-c oxidase assembly factors and mitochondrial translation regulators.