PDS5 — Schizosaccharomyces pombe 972h-

Summary

SPAC110.02, designated PDS5 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a chromatin adaptor with cohesin unloader activity and DNA binding capability, belonging to the ARM-type fold protein family. The gene is associated with sister chromatid cohesion, mitotic and meiotic chromosome segregation, spindle assembly and checkpoint control, centromere separation, and chromatin silencing. It localises to chromatin, the nucleus, centric heterochromatin, subtelomeres, and the mating-type region heterochromatin. Phenotypic associations link PDS5 to abnormal cell fusion, increased aneuploidy, premature chromosome segregation, delayed cell cycle progression through metaphase and G2/M transition, increased thermotolerance and fermentative growth, altered chitin deposition, and increased resistance to UV and ionizing radiation. Studies of related genes in other species connect the family to meiotic arrest.