CP9 — Schizosaccharomyces pombe 972h-

Summary

SPAC1296.03C, also known as CP9 or sxa2 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a serine carboxypeptidase (EC 3.4.16.-) belonging to the peptidase S10 family. This gene is associated with negative regulation of the pheromone response MAPK cascade, downregulation of conjugation with cellular fusion, and processes including mating, sporulation, meiosis, apoptosis, and cell cycle control. It has been linked to G1 phase, secretion, proteolysis, cell growth, and hypersensitivity. The encoded protein localizes to the trans-Golgi network, extracellular, cytosol, and nucleus. Related genes in other species, such as KEX1 and cpdS, connect the family to carboxypeptidase activity (EC 3.4.16.5 and 3.4.16.6) and associations with plant pathogens like Verticillium dahliae and Fusarium oxysporum.