MRE11 — Schizosaccharomyces pombe 972h-

Summary

SPAC13C5.07, also known as MRE11, encodes the Rad32 protein, a nuclease with double-stranded DNA 3'-5' exonuclease and single-stranded DNA endonuclease activities, and is a component of the MRN complex. The gene is associated with DNA double-strand break processing, meiotic recombination, homologous recombination repair, and non-homologous end joining. It is linked to the mitotic G2 DNA damage checkpoint, the intra-S DNA damage checkpoint, and replication fork arrest. MRE11 is connected to telomeric regions and the site of double-strand breaks. Phenotypic associations include absent mitotic recombination and sporulation, altered cell cycle progression through G1/S and G2/M transitions, increased gamma ray resistance, and delayed vegetative and exponential growth. Studies of related genes in other species link it to oxidative stress response and potassium concentration.