PKC1 — Schizosaccharomyces pombe 972h-

Summary

SPAC15A10.08, also known as PKC1 or ain1 in Schizosaccharomyces pombe 972h- on chromosome 1, encodes a protein with an EF-hand calcium-insensitive domain, an actinin actin-binding domain, and a calponin homology domain, and is annotated for actin lateral binding, F-actin binding, protein binding bridging, and calcium ion binding. This gene is associated with formin-nucleated actin cable organization, actomyosin contractile ring organization, actin crosslinking, actin filament bundle assembly, contractile ring assembly, actin cortical patch organization, cell polarization, actin polymerization, MAPK cascade, pheromone response, and glucan anabolism. It localizes to the actin body, cortical actin cytoskeleton, actomyosin contractile ring, and actin patches. Phenotypic associations include decreased cell cycle progression, increased thermotolerance, increased virulence, abnormal mating response, abnormal spore germination, and decreased sporulation efficiency. Related genes in other species are linked to salt tolerance and acid sensitivity.