taz1 — Schizosaccharomyces pombe 972h-

Summary

SPAC16A10.07C (taz1) on chromosome 1 of Schizosaccharomyces pombe encodes a Myb-domain protein that binds double-stranded telomeric DNA and mediates protein homodimerization. The product is associated with telomere organization, assembly, capping, and protection from non-homologous end joining-mediated telomere fusion. It is linked to meiotic processes including telomere clustering, attachment to the spindle pole body and nuclear envelope, and kinetochore disassembly. The protein localizes to the chromosome telomeric repeat region, nuclear periphery, chromatin, and meiotic spindle pole body. Studies of related genes in other species further connect it to the telosome complex. Taz1 is also associated with astral microtubule organization, post-transcriptional gene silencing, and spindle pole body organization.