PAC1 — Schizosaccharomyces pombe 972h-

Summary

SpPAC1 (SPAC17C9.03) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with eIF-4G domains, including an eIF4G_eIF4E-binding domain, and is annotated with translation initiation factor activity, structural molecule activity, and mRNA binding. The gene is associated with cytoplasmic translational initiation, ribosomal large subunit biogenesis, and a wide range of RNA processing events including snRNA metabolism, tRNA processing, and mRNA processing. It is linked to cell cycle regulation, including DNA replication initiation, meiosis II, anaphase, and nuclear division, as well as mating type switching and DNA imprinting. Phenotypic associations include increased thermotolerance, altered sporulation, cell cycle arrest at multiple phases, abnormal chromosome segregation, and increased polyploidy. The protein localizes to the cytoplasm, nucleus, stress granules, and the perinuclear region.