CRM1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1805.17 (CRM1) on chromosome 1 of Schizosaccharomyces pombe encodes an exportin-1/importin-beta-like protein with an NES receptor molecular function and small GTPase and GTP binding activities. The gene is associated with nucleocytoplasmic transport, including nuclear export and import of ribosomal subunits and proteins, as well as copper export, chromatin silencing, MAPK cascade, response to oxidative stress and nutrient availability, microtubule nucleation, protein secretion, and spore germination. CRM1 localises to the nucleus, nuclear periphery, nuclear envelope, cytoplasm and cytosol. Phenotypic associations include abnormal cell cycle progression through G1/S and S phases, decreased nuclear import rate, absent nuclear export, premature chromosome segregation, abnormal ER and vesicle distribution, decreased nuclear fusion during mating, increased recovery from pheromone-induced arrest, delayed fermentative metabolism and protein transport, increased hydrostatic pressure resistance, and absent hyperosmotic stress resistance.