ASP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC186.03 (ASP1) in Schizosaccharomyces pombe encodes a probable L-asparaginase 1, a member of the L-asparaginase family with asparaginase activity (EC 3.5.1.1). The gene is associated with asparagine breakdown, cell quiescence, chromosome biorientation, mitochondrion distribution, polyphosphate metabolism, iron-sulfur cluster assembly, spindle assembly checkpoint, polar cell growth, cell morphogenesis, and regulation of gene expression. It localizes to the cytoplasm, periplasm, and cell bound compartments. Phenotypic associations include abnormal flocculation, absent or altered biofilm formation, increased or decreased adhesion, abnormal colony shape, decreased invasive growth, increased vegetative growth rate, absent pseudohyphal growth, decreased respiratory metabolism, increased G1 phase duration, increased innate thermotolerance, increased stress resistance, and increased replicative lifespan. Studies of related genes in other species link the family to filamentous growth and UV resistance.