ypt3 — Schizosaccharomyces pombe 972h-

Summary

SPAC18G6.03 (ypt3) on chromosome 1 of Schizosaccharomyces pombe encodes a small GTPase of the Rab family, possessing GTPase activity and GTP binding. This gene is associated with multiple membrane trafficking processes, including endosome-to-plasma membrane transport, Golgi-to-plasma membrane transport, and vesicle fusion. It is linked to cytokinesis, specifically contractile ring contraction and membrane addition at the site of mitotic cytokinesis, as well as to vacuole organization and fusion, and ascospore-type prospore assembly. The encoded protein localizes to the transport vesicle membrane, recycling endosome, cleavage furrow leading edge, and growing cell tip. Phenotypic associations include delayed vegetative growth and cell cycle progression, abnormal Golgi morphology and vesicle distribution, increased aneuploidy, and decreased cell fusion. Related genes in other species link it to additional secretory and endocytic trafficking regulators.