CTP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC19G12.05 (CTP1, SpCTP1) on chromosome 1 of Schizosaccharomyces pombe encodes a mitochondrial carrier protein of the TXTP-like family with citrate carrier, aspartate:glutamate antiporter, 2-oxoglutarate transporter, glycine transporter, dicarboxylic acid transporter, succinate:fumarate antiporter, L-aspartate and L-glutamate transmembrane transporter activities. The protein localises to the mitochondrial inner membrane and is associated with mitochondrial citrate, 2-oxoglutarate, L-ornithine, glycine, aspartate and glutamate transport, the malate-aspartate shuttle, recombinational repair, DNA double-strand break processing, gene conversion, non-homologous end joining, cell cycle checkpoint control, G1 phase, response to bleomycin, and heme and fumonisin anabolism. Phenotypic associations include increased respiratory metabolism, altered carbon and nitrogen source utilisation, increased autophagy, decreased acquired thermotolerance, decreased acid and alkaline pH resistance, decreased UV resistance, increased replicative lifespan, increased invasive growth, and altered growth rates.