cdc12 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F5.04C (cdc12) in Schizosaccharomyces pombe 972h- encodes a formin-family protein that binds F-actin, small GTPases, and is annotated with actin nucleation, barbed-end actin filament capping, and actin filament bundle assembly and organization. The gene is associated with protein localization to the mitotic actomyosin contractile ring, contractile ring assembly, regulation of cell division and mitosis, spindle breakdown, cytogamy, actin fusion focus formation, cellular bud site selection, establishment or maintenance of bipolar cell polarity, regulation of cell shape, and Golgi localization. It localizes to the actomyosin contractile ring proximal layer, cell cortex of growing cell tip, cellular bud neck split septin rings, mating projection, neck ring, medial cortex septin ring, Spitzenkorper, mating projection actin fusion focus, and midsome. Studies of related genes in other species link the formin family to actin organization and cell polarity.