ABP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC1F8.05 (ABP1, isp3) on chromosome 1 of Schizosaccharomyces pombe encodes a structural constituent of the ascospore wall and is localised to the Isp3 layer of the spore wall and the cytoplasm. The gene is associated with ascospore wall assembly, spore dispersal, mating-type switching, sex determination, karyogamy, meiosis II, heterochromatin organisation, centromeric silencing, nucleosome assembly, DNA replication initiation, interphase, spindle elongation, suppression of meiotic recombination, gene conversion, donor selection, and membrane breakdown. Phenotypic associations include abnormal spore wall formation, decreased cell fusion, absent cell fusion, abnormal filamentous growth, decreased adhesion, decreased pheromone sensitivity, increased alkaline pH resistance, decreased anaerobic growth, decreased necrotic cell death, decreased fermentative metabolism, increased respiratory metabolism, abnormal prion inheritance and formation, abnormal shmoo formation, abnormal chitin deposition, decreased chromosome segregation, delayed cytokinesis, and decreased endocytosis rate. Studies of related genes in other species link the family to actin-binding and SH3 domains.