hus1 — Schizosaccharomyces pombe 972h-

Summary

SPAC20G4.04C, the hus1 gene on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a protein belonging to the HUS1/Mec3 family and the DNA clamp superfamily. The gene is associated with the meiotic DNA integrity checkpoint, the DNA replication checkpoint, and the S-M checkpoint. It has been linked to response to radiation, regulation of DNA repair, recombinational repair, base excision repair, bypass DNA synthesis, and strand displacement. Additional associations include establishment of sister chromatid cohesion, telomere capping, replication fork arrest, programmed cell death, cellular respiration, and cell cycle phase and G2 phase. The protein localises to the nucleus, cytosol, nucleolus, mitotic spindle pole body, chromosome telomeric repeat region, and sites of double-strand breaks.