MBP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC22F3.09C (MBP1, also known as res2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein containing SWI6-like and APSES-type helix-turn-helix domains, along with ankyrin repeats. The protein exhibits promoter-specific chromatin binding, DNA-binding transcription repressor and activator activities for RNA polymerase II, and transcription coactivator activity. It is associated with the MBF and SBF complexes, localizes to chromatin, cytoplasm, cytosol, and nucleus, and is linked to regulation of the mitotic and meiotic cell cycles, including G1/S transition, S phase, G2 phase, and anaphase. The gene has been associated with conidia formation, melanin and steroid metabolism, DNA replication, and mRNA/rRNA processing. Phenotypic associations include altered cell cycle progression, mating efficiency, pheromone sensitivity, gamma ray resistance, chronological lifespan, telomere length, and vegetative growth. Studies of related genes in other species link the family to virulence, desiccation resistance, and germination rate.