plo1 — Schizosaccharomyces pombe 972h-

Summary

SPAC23C11.16 (plo1) on chromosome 1 of Schizosaccharomyces pombe encodes a Polo-like kinase with serine/threonine kinase activity, specifically histone H3S10 kinase activity (EC 2.7.11.21). The gene is associated with multiple cell cycle processes, including centromere separation and localization, regulation of mitotic sister chromatid segregation, regulation of mitotic actomyosin contractile ring assembly, spindle breakdown, and meiotic spindle pole body organization. It is linked to cell tip growth, response to hydrostatic pressure, S-nitrosylation, and EMTOC assembly. The protein localizes to the spindle midzone, inner kinetochore, meiotic spindle, and septin ring, and is part of the CPC complex. Studies of related genes in other species link the family to loss of pathogenicity.