CAG1 — Schizosaccharomyces pombe 972h-

Summary

SPAC23H3.13C (CAG1, also known as gpa2) on chromosome 1 of Schizosaccharomyces pombe encodes a G-protein alpha subunit containing a Gprotein_alpha_su domain and a GproteinA_insert domain, with GTPase activity, GTP binding, and adenylate cyclase activator activity. The gene is associated with the heterotrimeric G-protein complex and localises to the cytoplasm, nucleus, mitochondrial outer membrane, mitotic spindle pole body, and cell division site. It is associated with glucose detection and response, the glucose-sensing PKA pathway, adenylyl cyclase activation, GPCR signalling, sexual reproduction, spore germination, invasive growth under glucose limitation, and tube formation. Phenotypic associations include altered mating efficiency, abnormal mating response, increased pheromone production, delayed sporulation, increased shmoo formation, increased polyploidy, and delayed cell cycle progression in telophase. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.