EAF3 — Schizosaccharomyces pombe 972h-

Summary

SPAC23H4.12 (EAF3, alp13) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with an MRG domain and a chromo-like domain and is annotated as a histone H3K36me3 reader. The gene is associated with nucleosome organization and disassembly, DNA replication-dependent chromatin assembly, DNA repair-dependent chromatin remodeling, and both positive and negative regulation of transcription by RNA polymerase II. It is associated with the TIP60 histone acetylase complex and localizes to the nucleus. Phenotypic associations include delayed cell cycle progression in G2 and metaphase, abnormal mitosis and meiosis, increased aneuploidy, decreased chromosome segregation, altered prion inheritance and formation, delayed mitophagy, increased X-ray resistance, and abnormal spore wall formation. Studies of related genes in other species link the gene family to the Rpd3S complex and oxidative stress response.