CPS1 — Schizosaccharomyces pombe 972h-

Summary

SPAC24C9.08, symbol CPS1 (SpCPS1) on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a metallocarboxypeptidase (EC 3.4.17.4) belonging to the peptidase M20 family, with carboxypeptidase and hydrolase activity acting on carbon-nitrogen bonds. The gene is associated with diverse biological processes including nucleoside and 1,3-beta-glucan anabolism, spore wall assembly, division septum assembly, vacuole fusion, microtubule nucleation, and membrane invagination. It localises to the fungal-type vacuole lumen and membrane, and extracellularly. Phenotypic associations link CPS1 to cell cycle progression (G2 phase duration decreased, G1 phase increased), recovery from pheromone-induced arrest, vacuolar transport, endocytosis, protein secretion, prion inheritance, sporulation efficiency, telomere length, and resistance to gamma rays, freeze-thaw, ionic stress, and chemicals. The gene is also associated with turgor pressure and altered carbon source utilisation.