pyp1 — Schizosaccharomyces pombe 972h-

Summary

SPAC26F1.10C, symbol pyp1, on chromosome 1 of Schizosaccharomyces pombe 972h-, encodes a protein tyrosine phosphatase with MAP kinase tyrosine phosphatase activity (EC 3.1.3.48). The product belongs to the protein-tyrosine phosphatase family and contains a rhodanese-like domain. Pyp1 is associated with regulation of mitosis, including positive regulation of mitotic entry and mitotic exit, as well as downregulation of mitosis. It is linked to the p38 MAPK cascade, both its regulation and downregulation, and to MAPK cascade processes generally. Additional associations include protein dephosphorylation, mRNA destabilization, nuclear transport and import, response to cadmium, osmotic response, cell morphogenesis, and regulation of cell growth. The protein localizes to the cytoplasm, cytosol, nucleus, mitochondria, and protein aggregate centers. Related genes in other species, including pyp2 and pyp3, link the family to similar regulatory roles.