ARK1 — Schizosaccharomyces pombe 972h-

Summary

ARK1 (SPAC2F7.10) on chromosome 1 of Schizosaccharomyces pombe encodes a protein-cysteine S-palmitoyltransferase (EC 2.3.1.225) containing a DHHC palmitoyltransferase domain and ankyrin repeats. The gene is associated with regulation of chromosome segregation, centrosome duplication, kinetochore assembly, sister chromatid segregation, chromosome condensation, and chromosome biorientation. It is also linked to TORC2 signaling, microtubule shortening, karyogamy, meiosis II, telophase, and protein membrane targeting. The product localizes to early endosome, Golgi, ER, and fungal-type vacuole membranes. Phenotypic associations include decreased endocytosis, delayed cytokinesis, abnormal filamentous and pseudohyphal growth, decreased mating-type switching, increased polyploidy, and delayed G2 phase progression. Studies of related genes in other species link the family to cell membrane stability and protein content.