LSP1 — Schizosaccharomyces pombe 972h-

Summary

SPAC3C7.02C (LSP1, also known as pil2) in Schizosaccharomyces pombe encodes a member of the PIL1/LSP1 protein family, which contains an AH/BAR domain superfamily fold and is annotated for lipid binding. This gene is associated with eisosome assembly, plasma membrane organization, cell motility, endocytosis, cytokinesis, sporulation, and MAPK signaling. It localizes to the eisosome, plasma membrane, prospore membrane leading edge, and meiotic spindle pole body. Phenotypic associations link LSP1 to abnormal cell cycle progression, defective cell fusion, absent meiosis, altered budding patterns, impaired recovery from pheromone arrest, abnormal shmoo formation, and increased necrotic cell death. The gene is also associated with plasma membrane morphology, protein transport, and spore germination. Studies of related genes in other species link the family to eisosome organization and copper sensitivity.