ATG13 — Schizosaccharomyces pombe 972h-

Summary

SPAC4F10.07C (atg13) in Schizosaccharomyces pombe 972h- encodes a protein with an Atg13_N domain and a HORMA domain superfamily, and has protein kinase regulator activity. This gene is associated with autophagy, macroautophagy, mitophagy, and nucleophagy, as well as protein localization to the phagophore assembly site (PAS), TOR signaling, response to starvation, protein secretion, spore formation, the meiotic cell cycle, and cell growth. It localizes to the PAS, cytoplasm, and cytosol. Phenotypic associations include abnormal cell cycle progression, increased cell death, altered replicative lifespan, increased anaerobic growth, increased hydrostatic pressure and freeze-thaw resistance, decreased entry into G0, decreased utilization of nitrogen sources, and abnormal pseudohyphal growth. Related genes in other species link it to the ULK complex and oxidative stress response.