GIN4 — Schizosaccharomyces pombe 972h-

Summary

SPAC57A10.02 (GIN4, also known as cdr2) on chromosome 1 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with dual-specificity protein kinase activity, protein kinase A activity, and phospholipid binding, and is associated with signaling adaptor activity. It is associated with division plane positioning, contractile ring assembly, septin ring organization, and the G2 cell size control checkpoint. The gene is linked to cell cycle progression through the G2/M phase transition, cytokinesis, and microtubule dynamics, as well as response to radiation and negative regulation of cytoplasmic translation. Localization evidence connects it to the interphase node, medial ring, cellular bud neck septin ring, and mitotic spindle pole body. Phenotypic associations include premature cell cycle progression, delayed cytokinesis, increased mating efficiency, and abnormal filamentous growth. Studies of related genes in other species link the family to cell cycle regulation and septin organization.