GIN4 — Schizosaccharomyces pombe 972h-

Summary

SPAC644.06C (GIN4, also known as cdr1) on chromosome 1 of Schizosaccharomyces pombe encodes a protein kinase with dual-specificity protein kinase activity and protein kinase A activity, containing a protein kinase domain and ATP-binding site. It also has signaling adaptor activity and binds phospholipids. The gene is associated with negative regulation of cell cycle, G2 cell size control checkpoint, and septin checkpoint. It localizes to the interphase node, septin ring, and cellular bud neck. Phenotypic associations link GIN4 to cell cycle progression through G2/M phase transition, cytokinesis timing, spore germination rate, mating efficiency, and filamentous growth. The gene is also associated with response to radiation and regulation of invasive growth in response to glucose limitation. Studies of related genes in other species connect the family to oxidative stress response and loss of pathogenicity.