ASC1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6B12.15 (symbol ASC1, also known as cpc2) on chromosome 1 of Schizosaccharomyces pombe encodes a RACK1-like WD40-repeat protein that is a structural constituent of the ribosome and is associated with signaling receptor activator activity. The gene product is associated with multiple cellular processes including GPCR signaling, GCN2-mediated signaling, regulation of cytoplasmic translation, ribosome hibernation, positive regulation of autophagy, and response to glucose. It localizes to the cytosolic small ribosomal subunit, ribosome, cytoplasm, nucleus, and plasma membrane. Phenotypic associations include abnormal pseudohyphal growth, increased adhesion, premature apoptosis, delayed anaphase progression, decreased meiosis, increased polyploidy, decreased ribophagy, and altered cell cycle progression in G2 phase. The gene is also linked to regulation of amino acid and methionine metabolism, mRNA destabilization, and negative regulation of the p38 cascade and cell integrity MAPK cascade.