FRH — Schizosaccharomyces pombe 972h-

Summary

SPAC6F12.16C (FRH, mtr4) on chromosome 1 of Schizosaccharomyces pombe encodes an RNA helicase with ATP hydrolase and nucleic acid binding activities, belonging to the SKI2-like helicase family. The gene is associated with diverse RNA processing pathways, including polyadenylation-dependent non-coding RNA catabolism, sno(s)RNA processing, siRNA catabolism, nuclear mRNA surveillance of spliceosomal pre-mRNA splicing, and the TRAMP-dependent tRNA surveillance pathway. It is linked to heterochromatin island assembly, degradation of meiosis-specific transcripts, non-stop decay, and 3'-5' nonsense-mediated decay. The encoded protein localises to the nucleolus, spliceosome, Ski complex, NURS complex, and nuclear bodies. Phenotypic associations include abnormal cell cycle progression, chromosome segregation defects, altered RNA accumulation, abnormal septum formation, and increased mitochondrial rho- mutation frequency. Related genes in other species connect the family to the TRAMP complex.