pcp1 — Schizosaccharomyces pombe 972h-

Summary

SPAC6G9.06C (pcp1, also known as RAD50 or SpRAD50) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with spindle pole body anchor activity and calmodulin binding. The gene is associated with centriole assembly, DNA double-strand break processing, recombinational repair, strand invasion, gene conversion, replication fork arrest, mitotic spindle assembly and elongation during prophase, karyogamy, spore wall assembly, cristae formation, and response to bleomycin, ionizing radiation, and hydroxyurea. It localizes to the mitotic and meiotic spindle pole bodies, central plaque, nucleus leading edge, and cytoplasm. Phenotypic associations include absent X-ray resistance and mitotic recombination, delayed shmoo formation, increased thermotolerance, altered cell cycle progression, decreased lifespan, and abnormal mating, sporulation, and transposable element transposition. Studies of related genes in other species link the family to potassium concentration and oxidative stress response.