SOD1 — Schizosaccharomyces pombe 972h-

Summary

SPAC821.10C (SOD1) on chromosome 1 of Schizosaccharomyces pombe encodes a copper-zinc superoxide dismutase, a protein with SOD_Cu/Zn domains that binds copper and acts as an oxidoreductase on sulphur-group donors with oxygen as acceptor (EC 1.15.1.1). The gene is associated with superoxide metabolism, cell redox homeostasis, copper ion transport, cellular copper and zinc ion homeostasis, response to zinc and glucose, glucose detection, protein oxidation and stabilization, folate metabolism, programmed cell death, flocculation, and cell organisation. It localises to the cytoplasm, cytosol, nucleus, mitochondrial envelope lumen, and extracellular space. Phenotypic associations link SOD1 to oxidative stress response, resistance to chemicals, desiccation resistance, freeze-thaw resistance, fermentative growth, spore germination, cell cycle progression through G1/S and G2/M transitions, mitochondrial genome maintenance, pexophagy, necrotic cell death, and nutrient uptake. Studies of related genes in other species connect the family to virulence and pathogenicity.