ARTA — Schizosaccharomyces pombe 972h-

Summary

SPAC8E11.02C (ARTA, rad24) on chromosome 1 of Schizosaccharomyces pombe encodes a 14-3-3 family protein with protein sequestering activity. The gene is associated with DNA modification, cell development, division plane positioning, microtubule destabilization, mitotic cytokinesis checkpoint, meiotic gene conversion, mating-type switching, and regulation of carbohydrate metabolism. It localizes to the actomyosin contractile ring, mitotic spindle midzone, cell division site, cell tip, and telomeric region. Phenotypic associations include increased acquired thermotolerance, premature cell cycle passage through metaphase-anaphase, increased sporulation, increased endocytosis, abnormal spore germination, delayed mitophagy, increased fermentative growth rate, and absent biofilm formation. Related genes in other species are linked to virulence, oxidative stress response, and potassium uptake.