RPB7 — Schizosaccharomyces pombe 972h-

Summary

RPB7 (SPACUNK4.06C) on chromosome 1 of Schizosaccharomyces pombe encodes a protein with an Rpb7-like N-terminal domain and an S1/OB-fold nucleic-acid-binding domain, and is annotated with translation initiation factor binding and single-stranded RNA and DNA binding activities. The gene product is a component of RNA polymerase II holoenzyme and core complex, localises to the nucleus, cytosol and P bodies, and is associated with transcription initiation and elongation from Pol II promoters, siRNA transcription, RNA processing, nuclear export, chromatin silencing, translation, and the DNA damage response. Phenotypic associations link RPB7 to decreased growth rate, abnormal cell cycle progression including G2/M phase delay and M phase arrest, defective cytokinesis, abnormal chromosome segregation, altered silencing, increased flocculation, and reduced utilisation of sulfur, phosphorus and iron sources. Related genes in other species are associated with DNA-directed RNA polymerase subunit function and acid sensitivity.