ABCA — Schizosaccharomyces pombe 972h-

Summary

SPAPB24D3.09C (symbol ABCA, preferred name pdr1) on chromosome 1 of Schizosaccharomyces pombe 972h- encodes an ABC transporter with ATP-coupled transmembrane transporter activity, ATP hydrolase activity and ATP binding. The gene is associated with negative regulation of the cell cycle, phytochelatin transport, division plane positioning, microtubule dynamics, septin ring organization, contractile ring assembly, sister chromatid segregation, response to radiation, response to antibiotic, response to iron, and demethylation. It localizes to the ER membrane and plasmalemma. Associations with traits include protein content and oxidative stress response. Phenotypic associations include abnormal small molecule transport, decreased vacuolar distribution, increased vacuolar transport, increased fermentative growth, decreased cell death, delayed mitophagy, abnormal replicative and chronological lifespan, and altered cell cycle progression. Studies of related genes in other species link the family to plant height, leaf number, root length, drought tolerance and phosphate content.