rti1 — Schizosaccharomyces pombe 972h-

Summary

The fission yeast gene rti1 (SPBC119.14) on chromosome 2 encodes a member of the Rad52 family of DNA recombination and repair proteins, possessing recombinase activity, DNA reannealing activity, and the ability to bind single-stranded, double-stranded, and damaged DNA. This gene is associated with multiple DNA repair processes, including double-strand break repair via single-strand annealing, single-strand break repair, resolution of recombination intermediates, and meiotic joint molecule formation. It is linked to meiotic cell cycle control, DNA integrity checkpoint regulation, and rDNA maintenance. The encoded protein localizes to the nucleus, chromatin, and sites of double-strand breaks, and is also associated with mitochondria. RTI1 has been connected to the oxidative stress response and responses to acetaldehyde and camptothecin. Studies of related genes in other species link the broader protein family to DNA repair functions.