ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC1289.11 (ARK1, also known as spf38) on chromosome 2 of Schizosaccharomyces pombe encodes a WD40-repeat-containing protein that is a component of the U5 snRNP and the Tup11/Tup12 repressor complex. The gene product is associated with dynein complex binding, microtubule plus-end binding, transcription corepressor activity, histone binding, and GTP binding. It is linked to regulation of chromosome segregation, centrosome duplication, kinetochore assembly, microtubule organizing center organization, and TORC2 signaling. Phenotypic associations include decreased RNA localization, delayed cytokinesis, abnormal filamentous growth, decreased endocytosis, increased polyploidy, and delayed cell cycle progression in G2 phase. The gene is also linked to galactose-specific flocculation, cellular homeostasis, and vesicle transport along microtubules. Studies of related genes in other species link the family to cell membrane stability, protein content, and phosphate content.