ARK1 — Schizosaccharomyces pombe 972h-

Summary

SPBC13A2.04C (ARK1, also known as ptr2) in Schizosaccharomyces pombe 972h- encodes a protein belonging to the PTR2 symporter family within the major facilitator superfamily, possessing dipeptide and tripeptide transmembrane transporter activity. The gene is associated with oligopeptide transport and dipeptide and tripeptide import across the plasma membrane, as well as RNA transport, regulation of chromosome segregation, centrosome duplication, chromosome condensation, kinetochore assembly, sister chromatid segregation, meiosis II, telophase, microtubule shortening, chromosome biorientation, centromere localization, TORC2 signaling, response to amino acid, galactose-specific flocculation, and protein positioning. The encoded product localizes to the plasma membrane, cell tip, fungal-type vacuole and its membrane, cell division site, and plasmalemma. Phenotypic associations include decreased RNA localization, altered budding patterns, delayed cytokinesis and G2 phase progression, abnormal filamentous and pseudohyphal growth, decreased endocytosis, increased polyploidy, and altered pheromone sensitivity and cell fusion.