CDC6 — Schizosaccharomyces pombe 972h-

Summary

SPBC14C8.07C (cdc18, also known as CDC6) on chromosome 2 of Schizosaccharomyces pombe encodes a member of the Cdc6/18 and ORC1/CDC6 protein family, containing AAA+ ATPase domains, with ATP hydrolase activity, chromatin binding, and DNA replication origin binding functions. The gene is associated with mitotic pre-replicative complex assembly, DNA replication licensing, mitotic S phase, meiotic S phase, DNA amplification, recombinational repair, oogenesis, syngamy, and galactose metabolism. It localizes to the nucleus, chromatin, nuclear replication fork, and pre-initiation complex. Phenotypic associations include altered cell cycle progression rates through G1, S, and G2 phases, increased G1/S phase transition duration, abnormal spore germination, absent sporulation efficiency, increased sporulation, abnormal nuclear fusion during mating, and increased nucleus size. Studies of related genes in other species link the family to MCM complex loading.