DNA2 — Schizosaccharomyces pombe 972h-

Summary

SPBC16D10.04C (DNA2) on chromosome 2 of Schizosaccharomyces pombe encodes a protein with 5' flap endonuclease, 5'-3' DNA/RNA helicase, and dsDNA-dependent ATPase activities, belonging to the Dna2/JHS1_DEXXQ-box family. The gene is associated with Okazaki fragment processing, replication fork reversal and arrest, strand displacement, removal of RNA primers in mitotic DNA replication, and nonsense-mediated mRNA decay. It localises to the replication fork, nucleolar chromatin, nuclear bodies, mitochondrial nucleoids, and sites of double-strand breaks. Phenotypic associations include absent sporulation efficiency, delayed shmoo formation, increased cell cycle progression through S phase and G1/S transition, decreased budding, premature chromosome segregation, and absent mating-type switching. The gene is also linked to intra-S DNA damage checkpoint effector processes, RNA polymerase III transcription termination, and telomeric repeat region maintenance.