RAD18 — Schizosaccharomyces pombe 972h-

Summary

SPBC1734.06 (RAD18, also known as rhp18) on chromosome 2 of Schizosaccharomyces pombe encodes a RING-type zinc finger protein with ubiquitin ligase activity, ssDNA-dependent ATPase activity, and ssDNA binding. It belongs to the Rad18 fungal family and contains a SAP domain and UBZ4 motif. The gene is associated with DNA repair processes including error-free and mutagenic post-replication repair, translesion synthesis, base excision repair, and interstrand crosslink repair. It is linked to responses to UV radiation, replication fork arrest, DNA condensation, and nuclear transport. Phenotypic associations include altered cell cycle progression through G1/S and S phases, increased transposable element transposition, delayed chromosome segregation and anaphase, abnormal meiotic recombination and meiosis arrest, delayed sporulation, and increased fermentative growth and adhesion. The protein localizes to chromatin and the nucleus. Studies of related genes in other species link the family to oxidative stress response and virulence.