AC1 — Schizosaccharomyces pombe 972h-

Summary

SPBC19C7.03 (AC1, cyr1) on chromosome 2 of Schizosaccharomyces pombe encodes an adenylyl cyclase with adenylate cyclase and A/G cyclase domains, and has adenylyl cyclase activity. The enzyme is associated with metal binding, localises to the plasma membrane and cytoplasm, and is linked to the glucose-sensing PKA pathway, including glucose detection, cAMP anabolism, and protein kinase A activation. It is associated with the regulation of cell division, cell cycle control, G1 phase, oogenesis, spore germination, pheromone response, and DNA anabolism. Associations include calcium sensitivity, and phenotypes such as altered cell cycle progression through G2/M, increased nutrient uptake and carbon source utilisation, increased fermentative and anaerobic growth, decreased lifespan, and abnormal colony colour, filamentous growth, and pseudohyphal growth. Studies of related genes in other species link the family to loss of pathogenicity.