GEF1 — Schizosaccharomyces pombe 972h-

Summary

SPBC19C7.11 (GEF1) on chromosome 2 of Schizosaccharomyces pombe encodes a putative anion/proton exchange transporter with a voltage-gated chloride channel core and CBS domains, and is annotated for voltage-gated chloride channel activity. The gene is associated with chloride transmembrane transport, exocyst localization, cell polarization, morphogenesis, cytokinesis, endocytosis, exocytosis, nuclear export, DNA replication and its checkpoint, interphase, cell growth and division, and cellular copper and iron ion homeostasis. It localizes to the chloride channel complex, early endosome, endosome, vacuolar, Golgi and ER membranes, and the plasmalemma. Phenotypic associations include absent or decreased mating response, pheromone sensitivity and cell fusion, increased pheromone production, sterile phenotype, cell cycle arrest in G1 and metaphase, decreased mating efficiency, increased mitotic recombination, abnormal protein secretion and transport, abnormal RNA localization and accumulation, decreased acid pH resistance, and decreased or absent respiratory growth.