PAT1 — Schizosaccharomyces pombe 972h-

Summary

SPBC19G7.10C (PAT1, pdc2) on chromosome 2 of Schizosaccharomyces pombe encodes a Pat1-like domain protein with RNA-binding activity. The gene is associated with numerous cell cycle processes, including mitotic M phase, meiotic G2 phase, G2 phase, and regulation of chromosome segregation, as well as centromere clustering and separation, sister chromatid segregation, and nucleus organization. It is linked to P body assembly and deadenylylation-dependent decapping, and localises to the cytoplasm, cytosol, nucleus, and P bodies. Phenotypically, PAT1 is associated with cell cycle progression through the G2/M transition, mating efficiency, apoptosis, thermotolerance, virulence, polyploidy, aneuploidy, fermentative metabolism, nucleophagy, pexophagy, prion inheritance and formation, hydrostatic pressure resistance, pseudohyphal growth, Golgi morphology, pheromone sensitivity, and nuclear fusion during mating.