TOR — Schizosaccharomyces pombe 972h-

Summary

SPBC216.07C (TOR, tor2) in Schizosaccharomyces pombe 972h- encodes a protein with histone H2A kinase activity, pre-rRNA and protein complex binding, and ATP binding, belonging to the PI3/4-kinase catalytic domain superfamily and containing FRB, FAT, and FATC domains. The gene is associated with TORC1, TORC2, and ATR-ATRIP complexes, and localizes to nucleolar chromatin, perinuclear cytoplasm, and telomeric chromosome regions. It is linked to carbohydrate and glucose homeostasis, calcium ion homeostasis, cell quiescence, reversible differentiation, contractile ring contraction, DNA damage response, signal transduction, tRNA transcription, and regulation of double-strand break repair. Phenotypic associations include abnormal cell cycle progression through G1/S phase transition, decreased polyploidy, absent sporulation efficiency, increased virulence, and altered carbon and nitrogen source utilization. The gene is also associated with oxidative stress response and vacuolar morphology.