CAG1 — Schizosaccharomyces pombe 972h-

Summary

SPBC24C6.06 (symbol CAG1, preferred name gpa1) on chromosome 2 of Schizosaccharomyces pombe encodes a fungal G-protein alpha subunit, a member of the heterotrimeric G-protein complex family that possesses GTPase activity, GTP binding, and G protein-coupled receptor binding. This gene is associated with glucose detection and response, adenylyl cyclase activation, protein kinase A activation, and the GPCR signaling pathway. It is linked to sexual reproduction, sporulation, spore germination, tube formation, kinetochore assembly, cell polarization, and regulation of the pheromone response MAPK cascade. Phenotypic associations include absent mating efficiency, abnormal mating response, increased pheromone production, altered cell cycle progression, delayed sporulation, increased polyploidy, and abnormal nuclear fusion during mating. The gene localizes to the heterotrimeric G-protein complex, plasma membrane, cytoplasm, and cortical dynamic polarity patches.