POL2 — Schizosaccharomyces pombe 972h-

Summary

SPBC25H2.13C, also known as POL2 or cdc20, encodes a protein with DNA-directed DNA polymerase activity, single-stranded DNA 3'-5' exonuclease activity, SUMO binding, 4Fe-4S cluster binding, and nucleotide binding, and belongs to the DNA polymerase B family. This gene is associated with DNA replication proofreading, leading strand elongation, CMG complex assembly, and base-excision and nucleotide-excision repair gap-filling. It is linked to mitotic and meiotic processes including the meiosis I/meiosis II transition, activation of meiosis, mitotic anaphase, chromosome biorientation, and the mitotic spindle checkpoint. Phenotypic associations include delayed cell cycle progression through G1/S and G2 phases, delayed vegetative growth, abnormal sporulation efficiency, increased gamma ray resistance, decreased spore germination rate, and altered mating type switching. The protein localises to the DNA polymerase epsilon complex, nuclear replication fork, and telomeric repeat region.