rec8 — Schizosaccharomyces pombe 972h-

Summary

SPBC29A10.14 (rec8) on chromosome 2 of Schizosaccharomyces pombe encodes a Rad21/Rec8-like protein with ATP-dependent ring closure activity and chromatin binding. This gene is associated with meiotic sister chromatid cohesion, homologous chromosome pairing, and centromeric cohesion, as well as meiotic stages including leptotene, zygotene, pachytene, diakinesis, and meiotic interphase. It is linked to strand invasion, chromosome biorientation, regulation of monopolar attachment, and the mitotic spindle checkpoint. The product localizes to the meiotic cohesin complex, meiotic spindle, condensed chromosome centric region, centric heterochromatin, chromatin, and nucleus. Related genes in other species link it to the cohesin complex.