ADE3 — Schizosaccharomyces pombe 972h-

Summary

SPBC2G2.08, also known as ADE3 or ade9 in Schizosaccharomyces pombe 972h- on chromosome 2, encodes a protein with methylenetetrahydrofolate dehydrogenase (NADP+) activity, 5,10-methenyltetrahydrofolate cyclohydrolase activity, and 10-formyltetrahydrofolate synthetase activity (EC 1.5.1.5, 3.5.4.9, 6.3.4.3). The gene is associated with tetrahydrofolate interconversion, folate biosynthesis, purine nucleotide and histidine anabolism, one-carbon metabolism, and mitotic and meiotic chromosome segregation, kinetochore assembly, centromere separation and localization, spindle checkpoint function, and microtubule dynamics. It is linked to increased acquired thermotolerance, altered cell cycle progression in G1 phase, decreased mitophagy and pexophagy, abnormal mitochondrial transport and genome maintenance, absent respiratory metabolism, increased mitochondrial rho- mutation frequency, decreased nutrient uptake and utilization, and increased sporulation efficiency. The protein localizes to mitochondria and cytosol.